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Tuesday, May 5, 2020 | History

3 edition of Inhibition of folate metabolism in chemotherapy found in the catalog.

Inhibition of folate metabolism in chemotherapy

the origins and uses of co-trimoxazole

  • 176 Want to read
  • 15 Currently reading

Published by Springer-Verlag in Berlin, New York .
Written in English

    Subjects:
  • Co-trimoxazole -- Physiological effect.,
  • Folic acid -- Antagonists.,
  • Folic acid -- Metabolism.,
  • Sulfamethoxazole -- Pharmacodynamics.,
  • Trimethoprim -- Pharmacodynamics.

  • Edition Notes

    Includes bibliographies and index.

    Statementcontributors, J.F. Acar ... [et al.] ; editor, George H. Hitchings.
    SeriesHandbook of experimental pharmacology ;, v. 64
    ContributionsAcar, J. F., Hitchings, George H. 1905-
    Classifications
    LC ClassificationsQP905 .H3 vol. 64, RM666.C567 .H3 vol. 64
    The Physical Object
    Paginationxxi, 457 p. :
    Number of Pages457
    ID Numbers
    Open LibraryOL3490864M
    ISBN 100387117822
    LC Control Number82010641

    Fig1: The 5-fluorouracil (5-FU) metabolism pathway. In tumour cells 5-FU is converted to 5-fluorodeoxyuridine monophosphate (5-FdUMP) by the action of orotate phosphoribosyltransferase. 5-FdUMP inhibits the DNA synthesis by competing with deoxyuridine monophosphate (dUMP) for binding to thymidylate synthase in a complex that is stabilized by the reduced folate 5,methylene . A folate receptor-targeting radiopharmaceutical consisting of a folate-containing tetrapeptide chelator to which technetium Tc 99m is linked. The folate component of folate receptor-targeted technetium Tc 99m EC20 binds to folic acid receptors, which are frequently upregulated in many types of tumor cells and activated macrophages.

    As effective as chemotherapy and radiation can be in the treatment of cancer, both come with a wide variety of well-known side effects. Nausea, vomiting and gastrointestinal symptoms are common, because rapidly dividing cells of the mucous membranes of the mouth, stomach and the intestines are often destroyed along with the cancer cells. Dietary reference intake []. Because of the difference in bioavailability between supplemented folic acid and the different forms of folate found in food, the dietary folate equivalent (DFE) system was established. 1 DFE is defined as 1 μg (microgram) of dietary folate, or μg of folic acid supplement.

      Folate mediated one-carbon cycle. Folic acid (vitamin B9) is a cofactor in one-carbon metabolism, acting as a shuttle for methyl groups that will be used in the metabolism of s-adenosyl methionine (SAM), de novo synthesis of purines and thymidylate. Dihydrofolate reductase (dhfr), an enzyme involved in the recycling of this cofactor, reduces dihydrofolate to tetrahydrofolate (THF), Cited by:   Chemotherapy • Chemotherapy (chemo) is a type of treatment that includes a medication or combination of medications to treat cancer. , inhibition of folate metabolism. 4-Trimethoprim: it act by inhibition of dihydrofolate reductase. 5- Isoniazid: act by compete with pyridoxine. *Isoniazid = Iso nicotinic acid hydrazid (INH.


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Inhibition of folate metabolism in chemotherapy Download PDF EPUB FB2

Inhibition of Folate Metabolism in Chemotherapy The Origins and Uses of Co-trimoxazole. Editors: Hitchings, G.H. (Ed.) Free Preview.

Inhibition of Folate Metabolism in Chemotherapy. Editors (view affiliations) George H. Hitchings. Inhibition of Folate Metabolism in Chemotherapy: The Origins and Uses of Co-trimoxazole (Handbook of Experimental Pharmacology): Medicine & Health Science Books @ hor: George H.

Hitchings. Find many great new & used options and get the best deals for Handbook of Experimental Pharmacology: Inhibition of Folate Metabolism in Chemotherapy: The Origins and Uses of Co-Trimoxazole 64 (, Paperback) at the best online prices at eBay.

Free shipping for many products. Inhibition of Folate Metabolism in Chemotherapy | The literature on co-trimoxazole (TMP jSMX) is voluminous, but in the main it consists of research reports.

The same can be said of various symposia that have appeared. This volume attempts to present the current status of this antibacterial combination in a series of topical reviews, each of which represents a comprehensive summary of a. Get this from a library. Inhibition of Folate Metabolism in Chemotherapy: the Origins and Uses of Co-trimoxazole.

[George H Hitchings] -- The literature on co-trimoxazole (TMP jSMX) is voluminous, but in the main it consists of research reports. The same can be said of various symposia that have appeared. This volume attempts to. Additional Physical Format: Online version: Inhibition of folate metabolism in chemotherapy.

Berlin ; New York: Springer-Verlag, (OCoLC) Christopher D. Willey, James A. Bonner, in Clinical Radiation Oncology (Third Edition), Antifolates: Methotrexate, Trimetrexate, Pemetrexed.

The antifolate methotrexate tightly binds dihydrofolate reductase (DHFR), thereby inhibiting folate metabolism. Through this inhibition, thymidylate synthesis is blocked and, therefore, purine biosynthesis as well. Early studies demonstrated that the effects of methotrexate (MTX) were related to an interference of folate metabolism.

This mode of inhibition was termed stoichiometric that implied that at concentrations of inhibitor inadequate to cause complete inhibition of enzyme, almost all of the MTX was enzyme bound.

"Folate" (vitamin B 9) refers to the many forms of folic acid and its related compounds, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid, folacin, and pteroylglutamic acid.

Historic names includedfactor vitamin B c and vitamin M. The terms "folate" and "folic acid" have somewhat Legal status: US: OTC.

In: Hitchings G.H. (eds) Inhibition of Folate Metabolism in Chemotherapy. Handbook of Experimental Pharmacology (Continuation of Handbuch der experimentellen Pharmakologie), vol Cited by: 8. This rendering of cancer metabolism is supported by many examples in which inhibition of an enhanced metabolic activity results in impaired growth of experimental tumors (3, 4).

In some cases, the particular metabolic liabilities of cancer cells have been translated into effective therapies in Cited by: And, the metabolism of bacteria has some major differences compared to our cells' metabolism. That means that, you guessed it, antibiotics that inhibit bacterial metabolism can be selectively toxic.

A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. There are only a few studies on the nucleotide metabolism of H. pylori, but together with the information derived from analyses of the genome of the bacterium, they have provided a wealth of information about the pathways of biosynthesis and degradation of pyrimidine and purine nucleotides, and showed that nucleotide biosynthetic enzymes are potential targets for antimicrobials designed.

To date, only two enzymes of folate metabolism have ever been targeted in malaria chemotherapy and prophylaxis, dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS).

The products of this pathway, reduced folate cofactors, are essential for DNA synthesis and the metabolism of Cited by: 2. Folate Chemistry and Metabolism. the role of folate in cancer has been studied in the context of antifolate and cancer chemotherapy.

Folate mediates the this will result in inhibition of. Cancer & Metabolism accepted for inclusion in SCIE. We are delighted to announce that Cancer & Metabolism has been accepted for inclusion in Science Citation Index Expanded (SCIE), a key database of Web of Science, published by Clarivate ngCancer & Metabolism will be published in the annual Journal Citation Reports, at which point it will receive the associated journal.

Chemotherapy Source Book, pp Baltimore, Williams & Wilkins, 6. Shih C, Gosset L, Gates S, et al: LY and its polyglutamates exhibit potent inhibition against both human dihydrofolate reductase and thymidylate synthase: Multiple folate enzyme inhibition.

Cancer Res 57(6), by: 2. Sigel C.W. () Disposition and Metabolism of Trimethoprim, Tetroxoprim, Sulfamethoxazole, and Sulfadiazine. In: Hitchings G.H. (eds) Inhibition of Folate Metabolism in Chemotherapy.

Handbook of Experimental Pharmacology (Continuation of Handbuch der experimentellen Pharmakologie), vol Cited by: 9. Pemetrexed (ALIMTA, LY, MTA) is a novel antimetabolite that inhibits at least three enzymes involved in the folate pathway.

These enzymes are thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase. Pemetrexed has demonstrated clinical activity in non-small cell lung cancer as well as in a broad array of other solid tumors, including Cited by: This page includes the following topics and synonyms: Medication Causes of Macrocytic Anemia, Medications Affecting Folate Metabolism, Medications Affecting Cobalamin, Medication Causes of Marrow Toxicity, Drug-Induced Macrocytic Anemia.Pemetrexed, a multitargeted anti-folate, has shown activity in various tumours, especially mesothelioma and non-small-cell lung cancer (NSCLC) for which it is routinely used (Adjei, ).

Pemetrexed inhibits at least three of the enzymes involved in folate metabolism, and pyrimidine and purine biosynthesis, as shown in Figure 1.